Changes and clinical signification of von Willebrand factor antigen, D-dimer and fibrinogen deg-radation products in patients with acute cerebral infarction
Abstract：Objective To explore the changes and clinical signification of von Willebrand Fator Antigen(vWF:Ag), D-dimer(DD) and Fibrinogen Degradation Products(FDP) in acute cerebral infarction patients.Methods Levels of vWF:Ag, DD and FDP were measured by immune nephelometry. The differences of vWF:Ag, DD and FDP were analyzed between two groups. And the levels of vWF:Ag, DD and FDP were fol-lowed up for one year after the event.Results Totals of 94 patients with acute cerebral infarction were included [56(59.6%) males and 38(40.4%) females]. 120 healthy controls were included in the control group[68(56.7%) males and 52(43.3%) females]. Levels of vWF:Ag and DD in patients group were higher than that in control group(P<0.01). The logistic regression analysis showed that increasing of vWF:Ag and DD were risk factors of acute cerebral infarction. Levels of vWF:Ag and DD were positive correlated with score of NIHSS(r=0.625,0.510;P<0.01). Level of vWF:Ag was positive correlated with DD(r=0.688,P<0.01). Levels of vWF:Ag, DD and FDP in patients with poor prognosis were higher than that in patients with good prognosis(P<0.05).Conclusions Levels of vWF:Ag and DD are signifiantly increased in acute cerebral infarction patients, and positive correlated with NIHSS score. Detection of vWF:Ag and DD in acute cerebral infarction patients is contributed to the judgment of severity and prognosis of the disease.
Keywords：Von Willebrand factorD-dimerFibrinogen degradation productsAcute cerebral infarction
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 388-391 )