Effects of operant-conditioning myofeedback therapy combined with conventional therapy on serum BDNF levels and motor function in patients with ischemic stroke
Abstract：Objective To evaluate the effects of operant-conditioning myofeedback therapy com-bined with conventional rehabilitation on serum brain-derived neurotrophic factor (BDNF) levels and motor function in patients with cerebral infarction.Methods A total of 73 patients with primary cerebral infarction were enrolled and were randomly divided into experimental group (EG) (n=38) and control group (CG) (n=35). The subjects in EG group underwent an eight-week myofeedback training. Subjects in both groups followed the same treatment schedule for physical therapy and routine medication. Before the beginning of the experimental proto-col and 8 weeks later, serum BDNF levels were measured, neurological function was assessed with the National Institutes of Health Stroke Scale (NIHSS), motor function was assessed with simplified Fugl-Meyer Motor As-sessment (FMA).Results After 8 weeks, the NIHSS scores were reduced, the serum BDNF levels were elevated and the FMA were improved in the both groups (P<0.01). While the changes were more significant in the EG group when compared to the CG group(P<0.05). In addition, in EG group, the variations in NIHSS and FMA were both positively correlated with the changes of serum BDNF levels (r=0.405,0.672;P<0.05).Conclusions Operant-conditioning myofeedback therapy combined with conventional rehabilitation therapy may up-regulate the serum BDNF lev-els, which is beneficial to the recovery of neurological function and improve motor function of patients with cere-bral infarction.
Keywords：Brain-derived neurotrophic factorCerebral infarctionOperant-conditioning myo-feedback therapyMotor function
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 339-342 )