Comparison of neuropsychological profile between patients with dementia with lewy bodies and Par-kinson disease dementia
Abstract：Objective To compare the differences of neuropsychological profile between patients with dementia with lewy bodies(DLB) and Parkinson disease dementia(PDD).Methods A total of 20 DLB patients and 56 PDD patients were recruited in this study. Mini-mental State Examination(MMSE), Clock-draw-ing Test(CDT), Neuropsychiatric Inventory(NPI), Activities of Daily Living Scale(ADL), Hamilton Depression Scale(HAMD) and Clinical Dementia Rate(CDR) were used to evaluate the cognitive function.Results A total of 60% of DLB patients had fluctuant symptoms, significantly higher than PDD patients(19.6%,P=0.001). In the moderate and severe stage of dementia, the NPI scores of DLB group were significantly higher than that of PDD group(P<0.05). In the mild dementia stage, the scores of the family life and personal hobby domain in CDR were higher in PDD patients than that in DLB patients(P=0.039). In the moderate and severe stage, the memory score(P=0.018), orientation score(P=0.010) and overall CDR score(P=0.028) in DLB group were higher than that in PDD group.Conclusions Comprehensive neuropsychological tests combined with clinical history can help identify DLB and PDD in dementia patients.
Keywords：NeuropsychologyDiagnosisDementia with lewy bodiesParkinson disease demen-tiaSeverity
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 317-321 )