Correlation between blood-brain barrier permeability and clinical prognosis in patients with Guil-lain-Barre syndrome
Abstract：Objective To explore the correlation between the blood-brain barrier dysfunction and clinical prognosis in patients with Guillain-Barre syndrome (GBS). Methods Totals of 78 patients with GBS in department of neurology were followed-up from January 2013 to June 2016. All patients were divided into two groups based on Hughes scale at 6 months:the good prognosis group (Hughes < 3) and poor prognosis group (Hughes ≥ 3). Clinical and biochemical data,as well as immunotherapy were analyzed. Results Between the good and poor prognosis groups,there were no significant differences in gender,age,onset season,proceeding infection,pneumonia,mechanical ventilation,cerebrospinal fluid protein,immunoglobulin G,IgG-index, intrathecal IgG synthesis rate within 24 hours,injury of nerve axonal and immunotherapy (P>0.05). There were statistically significant differences in score of muscle strength on admission and albumin CSF/serum ratio(QALB) (χ2=11.73,8.01;P<0.05). Blood-brain barrier dysfunction was positively correlated with clinical poor prog-nosis (r=0.32,P<0.01). Conclusions The blood-brain barrier dysfunction in patients with GBS is associated with poor prognosis. Therefore,blood-brain barrier permeability may be used to predict the prognosis of patient with GBS.
Keywords：Blood-brain barrieNeural immuneGuillain-Barre syndromeClinical prognosis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 248-251 )