Effects of pioglitazone on expressions of 11β-hydroxysteroid dehydrogenase type 1 in central ner-vous system of diabetic rats
Abstract：Objective To study the effects of pioglitazone (PGZ) on the expressions of 11β-hydroxys-teroid dehydrogenase type 1(11β-HSD1) in central nervous system of diabetic rats and its asociation with cog-nitive function.Methods Thirty male SD rats were equally randomized into Control group (C group), Diabetic group (D group) and Diabetes+Pioglitazone group (DP group). Morris-water maze was used to test the cognitive function after 8 weeks. Western Blot was used to detect the expressions of 11β-HSD1 in hippocampus and hy-pothalamus.Results In Morris water maze, the number of crossing the platform in D group were significantly less than C group and DP group (P<0.01). The 11β-HSD1 expressions in hippocampus and hypothalamus of D group were significantly increased than C group and DP group, while the 11β-HSD1 expressions of DP group were significantly increased than C group (P<0.01).Conclusion Pioglitazone may improve cognitive function in diabetic rats, partly through the decrease of 11β-HSD1 expressions in hippocampus and hypothalamus.
Keywords：Diabetes mellitusCentral nervous system11β-HSD1Cognitive functionPiogli-tazone
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 184-186 )