Effects of pioglitazone on expressions of peroxisome proliferator-activated receptor-γ in central ner-vous system of diabetic rats
Abstract：Objective To study the effects of pioglitazone on the expressions of peroxisome prolifer-ator-activated receptor-γ (PPAR-γ) in hippocampus and hypothalamus of diabetic rats and to explore the as-sociation between pioglitazone and cognitive function.Methods Thirty male SD rats were equally randomized into control group (C group), diabetic group (D group) and diabetes+pioglitazone group (DP group). The spatial learning and memory function were tested by Morris water maze after 8 weeks. Expressions of PPAR-γ in hippo-campus and hypothalamus were detected by Western Blot.Results In the Morris water maze, escape latencies of D group increased significantly compared to C group and DP group(P<0.05). The expressions of PPAR-γ in hippocampuses and hypothalamuses of D group were significantly lower than C group and DP group(P<0.05). Conclusions Pioglitazone could increase the expressions of PPAR-γ in hippocampus and hypothalamus of dia-betic rats, which may be related to the improvement of spatial learning and memory function caused by pioglita-zone.
Keywords：Diabetes mellitusCentral nervous systemPPAR gammaCognitive functionPioglitazone
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 34-36 )