Effects of Shensong Yangxin capsule on the changes of electrocardiogram and myocardial enzyme in patients with refractory schizophrenia treated with clozapine
XIAO Hui-qiong
YUAN Li-li
Abstract：Objective To investigate the effects of Shensong Yangxin capsule on the changes of electrocardiogram(ECG)and myocardial enzyme in patients with refractory schizophrenia treated with clozapine.Methods The 102 refractory schizophrenia patients with normal ECG and serum myocardial enzyme level were recruited in this study,which were randomly divided into control group (n = 50)and observation group (n = 52).The control group was only treated by clozapine,while the observation group was treated by clozapine combined with Shensong Yangxin capsule.The PANSS score,ECG and serum levels of CK and CK - MB were detected at base - line and the 8th weeks of treatment. Results (1)There was no statistical difference of drug efficacy and serious adverse event between control group and observation group (P > 0.05),(2)The total incidence for abnormal ECG was 21 (42.0%)in control group and 12 (23.1%)in observation group,the difference was statistically significant between the two groups (P < 0.05).Sinus tachycardia was the most common abnormal ECG,the incidence was 1 6 (32.0%)in control group and 8(1 5.4%)in observation group,the difference was statistically signifi-cant between the two groups (P < 0.05).There was no correlation between the abnormal ECG and effi-cacy.(3)The serum levels of CK and CK- MB were elevated after treatment (P < 0.05),and were more lower in the observation group (P < 0.05).Conclusions Shensong Yangxin capsule could alleviate abnormal ECG and myocardial enzyme in patients with refractory schizophrenia treated with clozapine.
Keywords：Refractory schizophreniaElectrocardiogramMyocardial enzymeShensong Yangxin capsuleClozapine
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 544-546 )