Association of DISC1 gene polymorphism with Alzheimer disease in Han population from Shanghai
Abstract：Objective To explore the association of single nucleotide polymorphisms (SNP)in rs821 633 and rs1000731 of Disrupted in Schizophrenia 1 (DISC1 )gene with Alzheimer disease (AD). Methods DNA of 441 AD patients (case group)and 749 healthy controls (control group)of Han popu-lation in Shanghai were extracted.Genotypes in rs821 633 and rs1000731 of DISC1 gene were detected by Taqman SNP genotyping technology.The frequency distributions of genotypes in case group and control group were compared.Results rs821 633 was excluded because its genotype distributions were not con-sistent with the Hardy-Weinberg equilibrium in two groups.The genotype distributions of rs1000731 in two groups were consistent with the Hardy - Weinberg equilibrium.The differences in genotype and allele frequency in rs1000731 between two groups were not statistically significant (P > 0.05). Conclusions rs1000731 of DISC1 gene may not associated with AD.
Keywords：Alzheimer diseasePolymorphismsingle nucleotideDISC1 gene
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 503-505 )