Effect of paroxetine and Danzhi Xiaoyao Capsule on depression and sleep disorder in females with perimeno-pause
Abstract：Objective To observe the treatment effect of paroxetine and Danzhi Xiaoyao Capsule on depression and sleep disorder in females with perimenopause .Methods An open - controlled study was carried out ,sixty patients were allocated into paroxetine and Danzhi Xiaoyao Capsule treatment group (observation group ,29 cases) ,paroxetine treatment group (control group ,31 cases) .After 4 weeks ,through testing the serum estradiol(E2) ,follicle - stimulating hormone(FSH ) and luteinizing hormone(LH) before and after treatment ,and the score changes of modified Kupperman Rating scale , Pittsburgh Sleep Quality Index(PSQI) and Hamilton Depression Scale (HAMD) were used to evaluate the clinical curative effect .Results One case of control group was dropped out .Sex hormone level ,the degree of physical symptoms ,PSQI and HAMD scores were no significant difference in the two groups before treatment .After treatment ,plasma E2 levels were increased in the two groups (P < 0.05) .So-matic symptoms significantly reduced in the observation group (Z = 3 .95 ,P < 0 .05) ,while the control group didnot change significantly .The scores of PSQI and HAMD scores were significantly decreased in the two groups after treatment (P < 0 .01) ,and the observation group decreased more significantly than the control group ,efficacy of observation group was better than control group .Conclusions Paroxetine can effectively relieve the depressive symptoms in female with perimenopause and improve sleep quality , with the treatment of Danzhi Xiaoyao Capsule ,the curative effect is better .
Keywords：PerimenopauseDepressionSleep disordersParoxetineDanzhi Xiaoyao Capsule
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 434-436,437 )