Association between RAB7L1 gene promoter polymorphism and Parkinson disease in Southwestern Chinese Han Population
LIU Quan-sheng
ZHANG Wen-ling
LIU Shu-dong
Abstract：Objective To discuss the association between rs1572931 polymorphisms in promoter of RAB7L1 gene and Parkinson disease (PD) in Southwestern Chinese Han population .Methods One sin‐gle nucleotide polymorphism (SNP) ,rs1572931 in RAB7L1 gene was genotyped in 243 PD patients and 455 healthy controls by polymerase chain reaction -restriction fragment length polymorphism (PCR-RFLP) method .All controls and PD patients were ethnically and geographically matched .Differences of allele and genotype frequencies distributions between two groups were compared .Results A significantly de‐creased rs1572931 T allele frequency (27 .98% vs 34 .18% ,P=0 .019 ,OR=0 .748 ,95% CI=0.588 -0.952) and TT genotype frequency (4 .94% vs 10 .99% ,P= 0 .008 ,OR= 0 .421 ,95% CI= 0 .220-0.806) were found in PD group compared with control group .Conclusions TT genotype of rs1572931 in RAB7L1 gene may be a protective factor of PD in Southwestern Chinese Han Population .
Keywords：Parkinson diseasePolymorphismsingle nucleotideRAB7L1Association
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 297-299 )