Efficacy and safety of dual antiplatelet therapy in mild symptomatic carotid stenosis with vulnerable plaque
WU Qi
CHEN Liang
Abstract：Objective To explore the efficacy and safety of dual antiplatelet therapy in mild symp‐tomatic carotid stenosis with vulnerable plaque .Methods Totals of 205 patients with symptomatic low -grade stenosis (<50% ) and vulnerable plaque were randomly divided into the mono antiplatelet group (102 cases) and the dual antiplatelet group (103 cases) .The changes of serum MMP -9 ,the incidence of stroke and the adverse vascular events were compared within 90 days .Results After 21 days of treat‐ment ,the declined MMP -9 level of the dual -group was higher than the mono -group [(96 .86 ± 16 .52) ng/ml vs (77 .26 ± 13 .71) ng/ml ,P< 0 .01] .The total and ipsilateral stroke recurrence rates of the dual-group was less than the mono -group (3 .88% vs 11 .76% ,P = 0 .035 ;1 .94% vs 8 .82% , P = 0 .029) ,while there was no significant difference on the contralateral stroke recurrence rates be‐tween two groups (1 .94% vs 2 .94% ,P= 0 .643) .There were no significant difference in the incidences of bleeding (0 .97% vs 0 ,P = 1 .000) and acute coronary syndrome (1 .94% vs 5 .88% ,P = 0 .145) . Conclusions Dual antiplatelet therapy may have an advantage over mono antiplatelet therapy for mild symptomatic carotid stenosis with vulnerable plaque .
Keywords：Randomized controlled trialDual antiplatelet therapyVulnerable plaqueSymptomatic carotid artery stenosisMMP-9
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 186-188,191 )