Efficacy and safety of Yangxin decoction addition and subtraction with escitalopram oxalate tablets in treat-ment of depression

doi:10.3969/j.issn.1009-6574.2016.02.015

Abstract：Objective To explore the efficacy of escitalopram oxalate tablets combined with Yan‐gxin decoction addition and subtraction in treatment of depression .Methods Selected 68 cases of patients with depression that in line with group standards (total score of HAMD ≥18 points) and treated in our hospital from January to December in 2014 .These patients were divided into study group and control group randomly ,34 cases of each group .Patients in the study group received escitalopram oxalate tablets and Yangxin decoction addition and subtraction treatment for 8 weeks .Patients in the control group only were treated with escitalopram oxalate tablets for 8 weeks .We assessed the clinical curative effect by HAMD before and after treatment in 1 ,2 ,4 ,6 ,8 weeks .TESS was used to assess the adverse reaction . Results The HAMD scores decreased significantly in two groups after treatment , HAMD scores of study group was lower than the control group after treatment in the 8th week ,the differences were sta‐tistically significant (P<0 .05) .The total effective rate of study group was 100 .0% ,significantly higher than 82 .3% in the control group ,meanwhile ,the adverse reaction of study group was 0 ,significantly lower than 14 .7% in the control group , the differences were statistically significant ( P< 0.05 ) . Conclusions Using escitalopram oxalate tablets combined Yangxin decoction addition and subtraction in the treatment of depression is better than the treatment effect of using escitalopram oxalate tablets only , with rapid onset and fewer adverse reactions .