Simple drugs and drugs combined with repetitive transcranial magnetic stimulation on the treatment of audi-tory hallucination in first-episode schizophrenia patients：a randomized controlled study
Abstract：Objective To explore the efficacy and safety of the simple drugs and drugs combined with repetitive transcranial magnetic stimulation (rTMS) on the treatment of auditory hallucination in first -episode schizophrenia patients .Methods Totals of 80 first -episode schizophrenia patients with auditory hallucination were randomly divided into study group (40 cases ,rTMS + risperidone) and con‐trol group (40 cases ,risperidone) .PANSS and adverse reactions were assessed before treatment ,and after 1 ,2 and 4 weeks treatment to evaluate the efficacy and safety .Results The PANSS total score and each factor points were significantly decreased in the study group and the control group after 4 weeks treatment (P<0 .01);the markedly effective rate of PANSS positive symptoms factor in the study group (30% ) was higher than that of the control group (10% ) after 4 weeks treatment (P<0 .05);the PAN‐SS total score and positive symptoms factor in the study group were lower than those of the control group after 2 weeks and 4 weeks treatment (P<0 .05) .There was no significant difference in the incidence of adverse reactions between two groups (P>0 .05) .Conclusions rTMS can reduce the onset time and en‐hance the efficacy of drug therapy of auditory hallucination in schizophrenia with good safety .
Keywords：SchizophreniaRandomized controlled trialRepetitive transcranial magnetic stimulationAuditory hallucinations
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 138-141 )