Changes ofβ2 -microglobulin in patients with first episode schizophrenia
CHEN Yan
ZHU Li-ping
CHEN Mei-juan
Abstract：Objective To explore the changes and clinical significance of β2 -microglobulin (β2 -MG) in patients with first episode schizophrenia.Methods β2 -MG was examined in schizophrenia pa-tients (n= 60)and healthy controls (n= 60).PANSS was used to assess the clinical symptoms in schiz-ophrenia patients.Results Serumβ2 -MG was significantly higher in schizophrenia patients than healthy con-trols (P< 0.05);there was a significant positive correlation betweenβ2 -MG level and PANSS score (r =0.477 ,P< 0.001) ,negative score (r= 0.422 ,P= 0.001) and general pathology score (r= 0.391 ,P=0.002);there was no correlation with the positive scores (r= 0.107 ,P= 0.418).Conclusions β2 -MG may have a potential role in the pathogenesis of schizophrenia.Its concentration can be used as an indica-tor of immune function in schizophrenia patients.
Keywords：Schizophreniaβ2 -microglobulinImmunity
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 58-60 )