The effect of repetitive trascranial magnetic stimulation on memory function and hippocampus metabolism in patients with alcohol dependence
Abstract：Objective To explore the effect of repetitive trascranial magnetic stimulation on the memory function and the changes of hippocampus metabolism in detoxified alcohol dependent patients. Methods Totals of 38 detoxified alcohol dependent patients were randomly divided into two groups:rT-MS group with 1Hz ,over right dorsolateral prefrontal cortex (DLPFC) for 4 weeks ,and sham rTMS group with no effective simulation.All subjects were assessed by Hopkins Verbal Learning Test -Re-vised and Brief Visuospatial Memory Test-Revised to evaluate their verbal and visual memory function , and proton magnetic resonance spectroscopy (1 H -MRS) to test the level of N -acetyl aspartic acid (NAA) ,choline compounds (Cho) ,creatine compounds (Cr) of bilateral hippocampus.Results (1)The verbal memory and visual memory scores of rTMS group were significantly increased after treatment (P <0.05) ,while there was no significant difference on memory scores in sham rTMS group before and after treatment (P> 0.05).After treatment ,only visual memory score in rTMS group was significantly high-er than that of the sham rTMS group (P< 0.01) ,and there was no significant difference on verbal mem-ory (P > 0.05).(2)Compared with pre-treatment ,NAA/Cr and Cho/Cr of bilateral hippocampus in rTMS group was significantly increased after treatment (P < 0.01) ,while there was no significant difference in sham rTMS group (P > 0.05).After treatment ,NAA/Cr and Cho/Cr of bilateral hippo-campus was significantly higher in rTMS group than that of the sham rTMS group (P< 0.01).(3)The difference in NAA/Cr of left hippocampus and Cho/Cr of right hippocampus between before and after treatment were positively correlated with verbal and visual memory respectively (P < 0.01). Conclusions rTMS can improve the memory function in detoxified alcohol dependent patients ,which may be related to the increased level of NAA/Cr and Cho/Cr of hippocampus.
Keywords：HippocampusRepetitive trascranial magnetic stimulationAlcohol dependenceMemory impairment1 H -magnetic resonance spectroscopy
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 38-40,45 )