Relationship between cognitive function and insulin resistance in elderly patients with type 2 diabetes melli-tus
Abstract：Objective To explore the relationship between cognitive function and insulin resistance in elderly patients with type 2 diabetes mellitus .Methods A total of 212 patients aged 60 and above with type 2 diabetes mellitus were divided into two groups :cognitive impairment group(case group ,n= 100) and non-cognitive impairment group(control group ,n= 112) .The gender ,age ,education level ,BMI , TC ,TG ,LDL -C ,Cr ,FPG ,FINS and HOMA -IR were compared between the two groups ,and lo‐gistic regression was analyzed .Results In case group ,education level was lower (33 .00% vs 53 .57% , P < 0 .01) ,the level of BMI[(28 .7 ± 4 .5)kg/m2 vs (23 .9 ± 3 .7)kg/m2 ,P < 0 .01] ,FINS[(21 .8 ± 5.3)mU/L vs (12 .9 ± 3 .9)mU/L ,P < 0 .01] ,HOMA -IR[(6 .9 ± 1 .7) vs (3 .9 ± 0 .9) ,P < 0 .01] were higher than the control group .In the logistic regression ,education level ,FINS and HOMA -IR were independent factors which affect the cognitive impairment .Conclusions The education level ,FINS and HOMA -IR were independent factors of cognitive impairment in elderly patients with type 2 diabetes mellitus .Insulin resistance is an important risk factor for the cognitive impairment in elderly type 2 dia‐betes patients .
Keywords：Diabetes mellitustype 2AgedInsulin resistanceCognitive function
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 463-465,466 )