Association between 5 - hydroxytryptamine receptor gene polymorphisms and Alzheimer disease with or without a history of depressive episode

doi:10.3969/j.issn.1009-6574.2015.05.007

Abstract：Objective To investigate the relationship between 5 -hydroxytryptamine(5 -HT )1A and 5-HT2A receptor gene polymorphisms and Alzheimer disease(AD) with or without a history of de‐pressive episodes in Han Chinese .Methods With the method of case -control study ,130 AD patients without history of depressive episodes ,85 AD patients with history of depressive episodes and 120 healthy old individuals were included .The 5-HT1A C(-1019)G and 5 -HT2A T102C polymorphisms were analyzed with the technique of polymerase chain reaction - restriction fragment length polymor‐phism(PCR-RFLP).Results (1)ThefrequenciesofalleleGandgenotypeG/C,G/Gof5-HT1Ain AD with depressive episodes were significantly higher than those in the normal control group and AD without depressive episodes (P < 0 .05) .No significant difference in frequencies of 5 -HT1A genotype and allele between AD without depressive episodes and the normal control group was found (P> 0 .05) . (2) The frequencies of allele C and genotype C/C of 5-HT2A in AD with depressive episodes were sig‐nificantly higher than those in AD without depressive episodes (P < 0 .05) .Compared with normal group ,the frequency of 5-HT2A C/C genotype was higher in AD with depressive episodes (P < 0 .05) and there was no statistical significance in alleles and other genotypes of 5 -HT2A (P > 0 .05) .There was no significant difference in 5 -HT2A allele and genotype frequency between AD without depressive episodesandthenormalcontrolgroup(P>0.05).Conclusions 5-HT1AC(-1019)G,5-HT2A T102C gene polymorphisms may play an important role in AD patients with depressive episodes .5 -HT1A allele G and 5-HT2A allele C may be the risk factors .