Influence of childhood abuse on BDNF levels in patients with depression

doi:10.3969/j.issn.1009-6574.2015.03.007

Abstract：Objective To explore the effects of childhood abuse on serum of BDNF level in pa‐tients with depression .Methods Totals of 98 patients with depression were included in this study .Using Child abuse Questionaire(CTQ) ,Hamilton Depression Scale(HAMD) ,Suicidal Ideation Scale(SIOSS) and Beck Hopelessness Scale(BHS) to assess the situation of childhood abuse ,severity of depression , suicidal ideation and severity of despair ;According to CTQ score ,the subjects were divided into abuse group (n= 32) and non-abused group (n= 66) .And selected 30 healthy people as the control group . The serum of BDNF levels were determined by Enzyme-linked Immunosorbent .Results All 98 cases of patients enrolled in 32(32 .65% ) had a history of childhood abuse .There were significant differences be‐tween the abuse group and the non-abused group in the first onset age ,sex ratio ,the total score of the HAMD-24 ,the total score of BSH and the total score of SIOSS .BDNF levels of abuse group (627 ± 36)pg/ml were lower than those in non -abused group [(743 ± 28)pg/ml;P < 0 .01] and the control group [(1 320 ± 39)pg/ml;P< 0 .01)] .BDNF levels of non -abused group were lower than control group (P< 0 .01) .Conclusions Depression in patients with childhood abuse has obvious influence on BDNF levels ,childhood abuse led to the decrease of BDNF level may be a risk factor as an adult suffering from depression .