Analysis of the clinical characteristics of patients with different gender in Cushing's disease:296 cases in a single center

doi:10.3969/j.issn.1009-6574.2015.03.005

Abstract：Objective To explore clinical characteristics of patients with different gender in Cushing's disease .Methods Clinical data of 296 patients with Cushing's disease were collected from March 2008 to December 2013 and divided into male group and female group in Peking Union Hospital . The gender differences of patients with Cushing's disease were statistically analyzed in demography ,clin‐ical manifestation ,endocrine features laboratory tests and tumor size .Results Sex ratio for patients with Cushing's disease for men and women was 1∶4 .92 .There was no statistically significant differences in the age of presentation between genders (the mean age at presentation was 28 .34 ± 10 .87 years old for male and 33 .78 ± 12 .26 years old for female ,P> 0 .05) .The sexual differences of most common clinical features are statistically different , such as hypertension , skin thickness , purple striae , chromatosis , ophthalmological defects and osteoporosis tend to occur in male (P < 0 .05) .The value of ACTH and morning blood cortisol was different between male and female (P< 0 .05) .ALT was elevated 1 .6-2 .0 times in patients with Cushing's disease .Pituitary tumor size measured by maximum diameter was less than 1 cm in both male and female .Conclusions Male patients are more than female on the pituitary ad‐renocorticotropic hormone adenoma .The sexual differences play an important role in clinical manifesta‐tion ,endocrine features for patients with Cushing's diseas .