Correlation between serum folate,homocysteine and P300 in patients with first-episode schizophrenia

doi:10.3969/j.issn.1009-6574.2015.03.003

Abstract：Objective To explore the correlation between serum homocysteine ,folate and P300 in first-episode schizophrenia patients .Methods Fifty patients with first -episode schizophrenia were se‐lected as patient group ,choosing the age and sex -matched 50 healthy people in hospital staff and com‐munity groups as control group ,all participants were sepatately tested serum folate ,homocysteine and P300 ,and assessing psychotic symptoms when patients enrolled by Positive and Negative Syndrome Scale(PANSS) .Results Compared with the control group ,the level of serum folate was lower than in patient group ,the difference was statistically significant (t=5 .14 ,P<0 .01);Serum homocysteine was higher than the control group ,the difference was statistically significant (t=4 .23 ,P<0 .01);Compared with the control group ,P300 amplitude was lower and the incubation period was higher in patient group , and the difference was statistically significant (t=2 .51 -3 .23 ,P<0 .05) .In patient group ,serum ho‐mocysteine and Cz ,Pz site of P300 latency was positively correlated (r=0 .36~0 .46 ,P<0 .05) ,serum homocysteine and Cz ,Pz point of P300 amplitude was negatively correlated (r= -0 .38 - -0 .51 ,P<0.05) .Conclusions The amplitude and latency of P300's changes in first-episode schizophrenia patients may be associated with serum homocysteine metabolism ,and with no direct correlation with serum folate levels .