Effects of pretreatment with different coil low-frequency repetitive transcranial magnetic stimulation on epileptic seizures in rats
Abstract：Objective To explore the effects of different exciting coil low -frequency repetitive tran‐scranial magnetic stimulation(rTMS) on rats with seizures induced by lihium-pilocarpine .Methods 60 wistar rats were randomly assigned into control group (n = 20) ,circular coil group (n = 20) and figure -8 shaped coin group (n = 20) .All animals were pretreated by rTMS ,the acute epileptic model was made by lihium-pilocarpine .All the rats were injected pilocarpine ,to observe the latency of seizures and be‐havioral manifestations within 90 min .Results Compared with the control group ,the latency of magnetic stimulation group was prolonged and the difference between the three groups was statistically significant (P < 0 .05);Magnetic stimulation between the two groups showed that the latency of 8 -shaped coil group was extender than the circular coin group ,the difference was statistically significant (P< 0 .05) . The scores of seizure level were significantly lower in the both stimulate groups relative to the control group ,difference among the three groups was statistically significant (P< 0 .05) .Seizure level scores of 8-shaped coil group significantly lower than those in the circular coil group ,the difference was statisti‐cally significant (P < 0 .05) .Conclusions The rats of circular coin group and 8-shaped coil group pre‐treated with rTMS led to a longer latency of seizure onset ,and figure-8 shaped coil showed the better anti-epileptic effects .
Keywords：T ranscranial magnetic stimulationEpilepsyLatencyLithium chloridePi-locarpineCoil
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 173-176 )