Effects of antihypertensive therapy on blood pressure variability and clinical outcome in patients with acute ischemic stroke

doi:10.3969/j.issn.1009-6574.2015.02.011

Abstract：Objective To explore the effects of antihypertensive therapy on blood pressure varia‐bility and the neurological prognosis in patients with acute ischemic stroke .Methods Among the patients in the Registry ,873 patients with first-ever acute ischemic stroke (within 24 hours of onset) who were functionally independent before onset were prospectively enrolled in the present study ,and were divided into intravenous antihypertensive group ,oral antihypertensive group and observation group based on ad‐mission blood pressure .Calculating the coefficient of variation (CV) within 24 hours ,and were divided into five sections go on analyzing .The clinical outcome at 3 month after onset was divided into a good neurological recovery ,neurological deterioration ,and a poor functional outcome .Results The highest probability of good neurological recovery was associated with the lowest risk of neurological deterioration and poor functional outcome at the levels of CV≤4 .0 ,it was still exist even if removing age-gender and potentially confounding factors .Through the C-statistics ,the odds ratios of CV were 0 .567 ,1 .566 and 1 .699 at a good neurological recovery ,neurological deterioration ,and poor functional outcome respec‐tively .Conclusions Antihypertensive treatment at acute phase of stroke have the dual role that lowering systolic /diastolic and blood pressure variability .Intravenous administration is better;the smaller of blood pressure variability ,the better of clinical prognosis .Clinical Trial RegistrationURL : .Chictr .org .Unique identifier:ChiCTR-TRC-14004804 .