Correlation study of serum HIF-1αlevel and cognitive impairment after stroke
QIAN Lai
XU Yun
Abstract：Objective To study the correlation between serum HIF-1αlevel and cognitive impair‐ment after stroke .Methods First-ever stroke patients were recruited and detected serum HIF-1αlevel in 24 hours after admission .Cognitive status was evaluated by a set of cognitive assessments 2 weeks af‐ter stroke .Relationships between the serum HIF -1α level and cognitive impairment after stroke were calculated by Pearson's correlation coefficient and logistic regression analysis .Results 137 cases in ac‐cordance with the degree of cognitive disorders in stroke patients were divided into the following groups:64 Non-cognitive impairment (NCI) ,37 vascular cognitive impairment with no dementia (VCIND) and 36 vascular dementia (VaD) .The findings indicated that the serum HIF-1αlevel of patients with VaD was higher than NCI group ,However ,the serum HIF-1αlevel of NCI group and VCIND group had no difference .Correlational analysis determined that HIF-1αhad significant relationships with the results of cognitive assessments .Conclusions Serum HIF -1αchanges may has important clinical significance in early diagnosis of cognitive impairment after stroke .
Keywords：HIF-1αCognitive impairment after stroke
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 118-121 )