Study on serum levels of IL-1β and IL-6 in patients with depression treated with paroxetine and cognitive-behavior intervention
Abstract：Objective To explore the relationship between the Cognitive-behavior intervention and dysfunction of cellular immunity in patients with depression.Methods Enzyme-linked Immunosorbent Assays (ELISA) was used to measure the serum levels of IL-1β and IL-6 in 25 depressive patients treated with paroxetine combined with Cognitive-behavior intervention (group A) and another 25 depressive patients treated with paroxetine alone (group B) and 20 healthy controls (group C). Results The study showed that before the treatment, than that in the control group(P<0.01). After a 4-week treatment, however, no the groups(P＞0.05). Conclusions The results suggest that there is immune activation in depression. Psychotherapy combined with paroxetine is more effective for depression than medication alone, and both can reduce the levels of IL-1β and IL-6.
Keywords：DepressionCognitive-behavior interventionIL-1βIL-6
Publication Date：2009-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 115-117 )