The Effect of Deep Brain Stimulation(DBS) on Resting- state Cerebral Glucose Metabolism of Advanced Parkinson's Disease
Abstract：Objective To study the effects of bilateral subthalamic nucleus (STN) stimulation onresting-state cerebral glucose metabolism of advanced Parkinson's disease, and investigate the mecha-nism of deep brain stimulation (DBS). Methods Seven consecutive advanced Parkinson' s diseasepatients (4 men, 3 women; mean age 64±4; mean H-Y disability scale 4.4±0. 65) with bilateral STNDBS underwent 2 times 18F-FDG/PET examinations at rest preoperatively and one month postopera-tively with STN stimulation on respectively. The unified Parkinson' s disease rating scale was used toevaluate the clinical state under each condition. Statistical parametric mapping (SPM) was used to inves-tigate regional cerebral metabolic rate of glucose (rCMRGlu) during STN stimulation in comparison withr CMRGlu preoperatively. Results STN stimulation improved the clinical symptoms obviously for eachpatient. The significant increase of rCMRGlu was found in bilateral lentiform nucleus, brainstem (mid-brain and pon), bilateral premotor area (BA6), parietal-occipital cortex and anterior cingulated cortex,and the marked decrease of it was noted in left limbic lobe and bilateral inferior frontal cortex (P ＜0.05). Conclusions Bilateral STN stimulation might activate the projection axon from STN and improvethe clinical symptoms of advanced PD patients, through improving both ascending and descending path-way from thebasalgangliaandincreasingthemetabolismofhigher-ordermotor controloffrontalcortex.
Keywords：Parkinson's disease Subthalamic nucleus Deep brain stimulation PET 18F-FDG
Publication Date：2003-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 433-436 )