The methodology of assessment of cerebrovascular reserve capacity
Abstract：Single-photon emission computed tomography (SPECT) was applied to measure cerebral flood flow (CBF) directly by using radioactive tracers (i. e. IMP, 99 mTc-HMPAO, 99 mTc-ECD and 133 Xenon), and is still taken as standard method even now. Positron emission tomography (PET) was applied to measure CBF indirectly, but it could measure the tissue's metabolism of oxygen, glucose or other chemical materials on which radioactive tracers were labelled. Dynamic MRI and fMRI were applied to evaluate CBF by means of deoxyhemoglobin /oxygenation-sensitive imaging. CT combined 133 Xenon-clearance method was taken as another standard method to measure CBF from 1978 even to today. After inhalation or injection of 133 Xenon, CT was required to scan, and the sensitivity and specificity were both over 60% by this method. Transcranial Doppler sonographic technique (TCD) was a noninvasive method to measure blood flow velocity easily, but it was not used to detect the reactivity until 1990. All above these techniques could not be used to measure the cerebrovascular reserve capacity (CRC) until some specious cerebrovasodilators were applied to detect the reactivity of cerebral blood vessels. Only after these vasodilators (i. e. injection of acetazolamide, inhalation of CO2 and apnea) were combined with above techniques, the assessment of CRC would become possible.
Keywords：Cerebrovascular reserve capacity (CRC) Cerebral blood flow (CBF) SPECT PET MRI CT TCD Acetazolamide (ACZ)
Publication Date：2003-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 269-272 )