Recent advances in the study of long-term potentiation( part Ⅲ) -LTP and Neurotrophin
Abstract：Long-term potentiation (LTP) is believed underlined learning and memory. Recent research has attracted to brain-derived neurotrophic factor (BDNF) that may affect synaptic plasticity in both short- and long-term actions at the synapse. In vitro, neurotrophin regulate neuronal differentiation, axonal and dendritic growth and repair, synaptic formation, and synaptic plasticity. Here we summarized the experimental evidence linking BDNF to LTP. BDNF plays a role in LTP induction and late phase maintenance. The actions of BDNF are mediated by the TrkB receptor tyrosine kinase. BDNF potentiate LTP by modulating the number of docked vesicles and the level of vesicle protein on pre-synapse to increase neurotransmitter release, and by inducing postsynaptic depolarization to open voltage dependent Ca2+ channels. We also introduced the effects of LTP on the secretion of the neurotrophin. The experimental evidence strongly supports a role for BDNF in synaptic plasticity and should prompt further exploration of their functions at the synapse.
Keywords：Long term potentiation Synaptic plasticity Brain-derived neurotrophic tactor
Publication Date：2002-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 305-309 )