Recent advances in the study of long-term potentiation(Part I)
Guangcheng Cui
Guilan Ye
Abstract：Long-term potentiation of synaptic activity is the most popular and widely researched model of synaptic plastic changes because it is believed underling learning and memory. Calcium influx mediated by NMDA receptor activation is responsible for the induction of NMDA receptor dependent LTP, whereas protein kinase A mediated calcium concentration increase in presynaptic site induced NMDA receptor independent LTP or mossy fiber LTP. Here we also summarized the current concept on brain slice as a preparation of LTP study, recent research of protein and protein kinase activity involved in LTP expression, and some other interesting findings contributed to LTP. In part two on the next issue, we will focus on BDNF and LTP, several activity-dependent genes which related to LTP and learning and memory, and introduce some interesting LTP related work.
Keywords：LTP (long-term potentiation) Brain slice Calcium NMDA receptor S100 prootein
Publication Date：2002-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 179-182 )