The Expression of LAMP2a and LRG1 in Esophageal Cancer Tissues and Its Predictive Value for Prognosis

ZHAO Jiuying; SUN Lili; LIU Jinxia

doi:10.15926/j.cnki.issn2096-7381.2026.02.006

Abstract：Objective To investigate the expression of lysosomal-associated membrane protein 2A(LAMP2a)and leucine-rich α-2-glycoprotein 1(LRG1)in esophageal cancer tissues,and to analyze their predictive value for prognosis.Methods A prospective study was conducted on 112 patients with esopha-geal cancer who were diagnosed and treated at Puyang People's Hospital hospital from March 2022 to March 2024.The cancer tissues and adjacent tissues were removed during the operation.The expressions of LAMP2a and LRG1 proteins were compared.The expressions of LAMP2a and LRG1 proteins in patients with different clinical characteristics was analyzed,and its correlation with clinical characteristics was discussed.The pa-tients were followed up for 1 a,and were divided into poor prognosis subgroup and good prognosis subgroup;the expressions of LAMP2a and LRG1 proteins in the two subgroups were compared.Cox regression was used to analyze the prognostic factors.The interaction between LAMP2a and LRG1 in the risk of poor prognosis was further analyzed,and its predictive value for prognosis was evaluated.Results The positive expression rates of LAMP2a and LRG1 protein in cancer tissues were higher than those in adjacent tissues(P<0.05).The positive expression of LAMP2a and LRG1 protein was positively correlated with TNM stage and lymph node metastasis,but negatively correlated with the degree of differentiation(P<0.05).The positive expression rates of LAMP2a and LRG1 protein in the poor prognosis subgroup were higher than those in the good prognosis subgroup(P<0.05).TNM stage,degree of differentia-tion,lymph node metastasis and positive expression of LAMP2a and LRG1 protein were independent prognostic factors(P<0.05).The OR of LAMP2a and LRG1 protein positive expression in the risk of poor prognosis was 7.023,and the interaction index was 1.405.The positive expression of LAMP2a and LRG1 protein showed a positive interaction in the risk of poor prognosis.The AUC value of combined prediction of LAMP2a and LRG1 positive expression was significantly higher than that of single index prediction(P<0.05).Conclusion The positive expression of LAMP2a and LRG1 protein in esophageal cancer tissues is closely related to clinical characteristics and prognosis,and the positive expression of LAMP2a and LRG1 protein has a positive interaction in the risk of poor prognosis.The combined detection of their levels has a higher predictive value for patient prognosis.