Application of Nano-drug-loading System in Combination with Multi-pathway Radiotherapy for Esophageal Carcinoma
ZANG Keyan
ZHAO Yali
YANG Pingjuan
ZHANG Wei
YU Ying
LI Jiayi
SHI Linlin
GAO Shegan
Abstract：Esophageal carcinoma is a typical malignant tumor.Its treatment usually includes surgery,chemotherapy and radiotherapy.In recent years,many innovative methods have emerged in the field of radio-therapy,which can enhance the sensitivity of cancer cells to radiation through drugs or other methods,while reducing the damage to the surrounding normal tissues,so as to improve the effect of radiotherapy for esopha-geal carcinoma.As a new drug delivery platform,nano-drug delivery system has the characteristics of size effect and high specific surface area,especially can achieve targeted drug release in vivo.Nano-drug delivery system shows great potential in enhancing the sensitivity of radiotherapy for esophageal cancer by changing the drug distribution in vivo,reducing toxicity and increasing orientation.This paper reviews the research progress of nano-drug delivery system in radiosensitization of esophageal carcinoma.The potential and advan-tages of the combination of radiosensitization and other therapeutic methods are discussed from several key as-pects of the current research on nano-drug delivery system.
Keywords：esophageal cancerradiation therapy sensitizationtargeted therapynanoparticles drug deliv-ery system
Publication Date：2024-12-30
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：6( 315-320 )