The Pathological Regression Pattern of Residual Tumor in Radical Specimens of Patients with Esophageal Squamous Cell Carcinoma after Preoperative Chemotherapy Combined with Immunotherapy
XI Lina
LI Junkuo
SUN Yuanyuan
YANG Haijun
Abstract：Objective To explore the pathological regression pattern of residual tumor in radical specimens of patients with locally advanced esophageal squamous cell carcinoma after preoperative chemotherapy combined with immunotherapy.Methods A retrospective analysis was performed on the specimens of 411 patients who underwent radical resection of esophageal cancer after 2-4 cycles of chemotherapy combined with immunotherapy.The specimens were classified and analyzed according to the regression direction of the residual tumor in the esophageal wall.Results Among the 411cases,70 cases(17.03%)were regressed into the lumen,14 cases(3.41%)were regressed into the fibrous membrane,7 cases(1.70%)were concentric regressed,199 cases(48.42%)were random regressed,and 120 cases(29.20%)were completely regressed.One case was not yet classified.Conclusion Random regression was the most common direction of residual tumor regression,followed by complete regression,concentric regressed was the least.The cases of complete regression provide new data support for the esophageal preservation treatment strategy for patients with esophageal cancer.
Keywords：esophageal squamous cell carcinomaimmunotherapychemotherapyresidual tumorregression pattern
Publication Date：2024-12-30
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：5( 241-245 )