Influencing Factors of Radiation Pneumonia after Low Dose Radical Radiotherapy for Esophageal Cancer in Plateau Area

ZHAO Dongmei; WANG Li; BAI Han; LU Fei; LI Lan; XIA Yaoxiong

doi:10.15926/j.cnki.issn2096-7381.2024.02.003

Abstract：Objective To analyze the factors influencing the occurrence of radiation pneumonia(RP)after radical radiotherapy for esophageal cancer in plateau area under the background of low dose based on longitudinal cohort.Methods A retrospective analysis was conducted on the data of 172 esophageal cancer patients who underwent radical radiotherapy at our hospital from July 2020 to June 2023.RP was rated ac-cording to the National Cancer Institute Common Adverse Reaction Terminology Evaluation Standard 5.0(CT-CAE 5.0).Clinical factors,traditional independent dosimetry characteristics and dose-interval variation char-acteristics were collected.Correlation analysis was performed for the features used to predict the occurrence of symptomatic RP,feature screening was performed with structural clustering,multi-factor analysis was per-formed with logisitc regression(LR),and visualization was performed with Python.Results The incidence of RP was 81 cases(47.09％)in 172 patients,including 53 cases(30.8％)in grade 1,13 cases(7.5％)in grade 2,12 cases(6.9％)in grade 3,and 3 cases(1.7％)in grade 4.123 patients(71.51％)received a low dose of≤50.4 Gy;Multivariate a-nalysis showed that physical strength score(PS),interstitial pneumonia(IP),and prescribed dose(plan_dose)were independent prognostic factors for RP.Conclusion Radical radiotherapy for esopha-geal cancer in plateau area is safe under low dose background,and the radiotherapy dose should be carefully determined for patients with poor physical scores and prior interstitial pneumonia.