Effects of Dexmedetomidine Combined with Sevoflurane on Stress Indexes,Cognitive Function,and HMGB1 Level in Patients Undergoing Radical Resection for Esophageal Cancer
CHEN Long
Abstract：Objective To study the effects of dexmedetomidine and sevoflurane on stress indexes,cerebral oxygen metabolism indexes,cognitive function,and HMGB1 content in patients undergoing radical resection of esophageal cancer.Methods 124 patients with esophageal cancer admitted to our hospital from January 2020 to December 2022 were randomly divided into a control group and an observation group,with 62 cases in each.The observation group was given dexmedetomidine before anesthesia induction,while the control group was given saline.The two groups used the same anesthesia induction and maintenance plan.The stress response indicators,brain oxygen metabolism indicators,postoperative cognitive impairment,and pe-ripheral blood HMGB1 levels were compared between two groups.Results At T0,there was no significant difference in cortisol(Cor),malondialdehyde(MDA)levels,cerebral oxygen uptake rate(CERO2),and arterial jugular vein oxygen content difference(Da-jvO2)between the two groups(P>0.05).At T1 and T2,the levels of Cor and MDA,CERO2,and Da jvO2 in the observation group were significantly lower than those in the control group(P<0.05).The incidence of postoperative cognitive impairment in the observation group(6.45%)was significantly reduced compared to the control group(22.58%)(P<0.05).The observation group showed a significant decrease in peripheral blood HMGB1 levels on the 1st and 3rd day after surgery(P<0.05).Conclusion Dexmedetomidine before anesthesia induction could relieve stress response,regulate cerebral oxygen metabolism,and reduce the incidence of postoperative cognitive dysfunction in patients undergoing radical resection of esophageal cancer.
Keywords：dexmedetomidineradical resection of esophageal carcinomastress indexcognitive functionHMGB1
Publication Date：2024-03-30
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：6( 44-48,75 )