Progress of Research on the Relationship between Oral Microorganisms and Esophageal Cancer
SUN Fanyue
YANG Yuxin
CHEN Hongwei
SHI Xinpeng
LUO Xiaoyong
WANG Baoyong
Abstract：Esophageal cancer is a common malignant tumor of the digestive system,and its etiology is complex and multifaceted.In addition to known factors such as genetic alterations,alcohol consumption,and smoking,several studies have suggested that oral microbiota may play a significant role in the occurrence and development of esophageal cancer.Due to the anatomical continuity between the oral cavity and the esophagus,these two sites have similarities in microbial composition.Therefore,alterations in oral microbiota may impact the microbial ecology of the esophagus,thereby influencing the development of esophageal cancer.This review aims to summarize the research progress on the relationship between oral microbiota and esopha-geal cancer and to compare the differences in their roles in esophageal squamous cell carcinoma and esopha-geal adenocarcinoma,with the goal of providing a theoretical basis for the early prediction and treatment of e-sophageal cancer.
Keywords：oral microorganismsesophageal canceresophageal squamous cell carcinomaesophageal adenocarcinoma
Publication Date：2023-12-30
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：10( 292-300,310 )