Targeting Immune Metabolism to Improve the Tumor Microenvironment
LIU Gu-yi
ZHOU Hong-yi
DING Jian-lan
CHEN Le-le
SUN Jiang-tao
Abstract：The growing field of immune metabolism has revealed promising indications for metabolic tar-gets to modulate anti-cancer immunity.Oncogene-driven changes in tumor cell metabolism can impact the TME to limit immune responses and present barriers to cancer therapy.These changes also reveal opportunities to reshape the TME by targeting metabolic pathways to favor immunity.Here we explore current strategies that shift immune cell metabolism to pro-inflammatory states in the TME and highlight the need of better replicate physiologic conditions to select targets,clarify mechanisms,and optimize metabolic inhibitors.
Keywords：immune metabolismtumor microenvironmentesophageal cancerimmunotherapy
Publication Date：2023-12-30
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：6( 279-284 )