Research progress on mechanism of Zuogui pill in treatment of common central nervous system disorders
HU Jingyu
HUANG Yang
ZHANG Mengdi
ZHANG Wenya
LI Linfeng
LIU Hong
Abstract：Central nervous system(CNS)disorders are multifactorial diseases characterized by progressive neuronal loss and synaptic dysfunction,with highly complex pathogenic mechanisms.Zuogui pill,a classical traditional Chinese medicine formula that nourishes yin,tonifies the kidney,and replenishes essence and marrow,is traditionally used for syn-dromes associated with true yin deficiency.Accumulating evidence suggests that Zuogui pill exerts neuroprotective and neurorestorative effects in CNS disorders through multi-target and multi-pathway mechanisms.In Alzheimer's disease(AD),Zuogui pill has been reported to modulate disease pathology by inhibiting the production and aggregation of β-amy-loid(Aβ),attenuating neuroinflammation,suppressing neuronal apoptosis,reducing oxidative stress,and regulating epi-genetic modifications.In ischemic stroke(IS),its protective effects are associated with the attenuation of oxidative stress and neuroinflammation,the promotion of neurotrophic factor secretion,and the enhancement of neurogenesis and angiogen-esis,thereby facilitating neural and vascular repair.In multiple sclerosis(MS),Zuogui pill may alleviate disease progres-sion by modulating immune and inflammatory responses and by inhibiting signaling pathways that restrict axonal regenera-tion.Collectively,elucidating the molecular and cellular mechanisms underlying the therapeutic effects of Zuogui pills in CNS disorders may provide a theoretical framework for further mechanistic investigations and support its clinical promotion.
Keywords：Zuogui pillcentral nervous system disordersAlzheimer's diseaseischemic strokemultiple sclero-sismechanism of action
Publication Date：2026-02-25
Online Publishing Date：2026-03-19(First online date of this platform, not the publication date of the document)
Pages：5( 132-136 )