Screening of core target genes of Xiaoyin granules in treating psoriasis and its mechanism
WANG Rui
LI Chengwei
LI Xiao
LIU Zhendong
Abstract：Objective To screen the core target genes of Xiaoyin granules for psoriasis treatment and to explore its potential mechanism based on network pharmacology and bioinformatics.Methods Potential active ingredients and tar-get genes of Xiaoyin granules were screened using the TCM Systems Pharmacology Database and Analysis Platform(TC-MSP).Psoriasis-related target genes were retrieved from the GeneCards database.The intersection of these two sets was identified as common target genes.These common targets were uploaded to the STRING database to construct a protein-pro-tein interaction(PPI)network.Topological analysis was performed with Cytoscape software to screen for core target genes.Gene Ontology(GO)functional enrichment and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analyses for the core targets were conducted via the Metascape platform.Differentially expressed genes(DEGs)between psoriatic lesions and normal skin were screened from the Gene Expression Omnibus(GEO)database.The intersection of these DEGs with the drug targets was taken to further identify key core target genes.Results A total of 197 active ingre-dients and 241 target genes of Xiaoyin granules were identified.There were 4,024 psoriasis-related target genes.Their in-tersection yielded 124 common target genes.PPI network analysis identified eight genes as core targets,including fatty ac-id binding protein 5(FABP5),serine/threonine kinase 1(AKT1),and prostaglandin-endoperoxide synthase 2(PTGS2).GO and KEGG enrichment analyses indicated that these core targets were primarily involved in regulating inflammatory re-sponse,immune response,and signaling pathways such as phosphatidylinositol 3-kinase(PI3K)-AKT,interleukin-17(IL-17),and lipid and atherosclerosis.GEO analysis identified 90 DEGs.Their intersection with the drug targets yielded FABP5 as the key core target gene.Conclusions The core target gene of Xiaoyin granules in treating psoriasis is FABP5.Its therapeutic effect is likely achieved through a synergistic mechanism involving multiple ingredients,targets,and pathways.
Keywords：psoriasisXiaoyin granulesnetwork pharmacologymolecular dockingfatty acid-binding protein 5
Publication Date：2026-02-25
Online Publishing Date：2026-03-19(First online date of this platform, not the publication date of the document)
Pages：5( 122-126 )