Value of multimodal magnetic resonance imaging combining DWI,T2* mapping,and SWI in the differential diagnosis of prostate cancer and benign prostatic hyperplasia
XIN Yujing
LIU Qing
LI Jing
Abstract：Objective To investigate the value of multimodal magnetic resonance imaging(MRI)combining diffusion-weighted imaging(DWI),T2* relaxation time quantitative imaging(T2* mapping),and susceptibility-weighted imaging(SWI)in the differential diagnosis of prostate cancer(PCa)and benign prostatic hyperplasia(BPH).Methods Thirty-five pa-tients with PCa were retrospectively enrolled as the PCa group,and 45 patients with BPH were enrolled as the BPH group.All patients underwent conventional prostate MRI,DWI,T2* mapping,and SWI.The apparent diffusion coefficient(ADC)value,T2* value,and the number of calcifications and microhemorrhages were obtained.Differences in these pa-rameters between the two groups were compared.A multivariate Logistic regression model was constructed to develop a combined diagnostic model.Receiver operating characteristic(ROC)curves were plotted to evaluate the diagnostic effi-cacy of each individual parameter and the combined models.Results The ADC and T2* values in the PCa group were sig-nificantly lower than those in the BPH group,while the number of microhemorrhages was significantly larger in the PCa group(all P<0.05).No statistically significant difference was found in the number of calcifications between the two groups(P>0.05).Single-parameter diagnostic models based on ADC value,T2* value,and the number of microhemorrhages yielded areas under the ROC curve(AUCs)of 0.930,0.866,and 0.661,respectively.The combined model incorporat-ing ADC and T2* values and the combined model incorporating ADC value,T2* value,and the number of microhemor-rhages,both constructed using multivariate Logistic regression analysis,achieved an AUC of 0.961.The AUCs of both combined models were superior to those of the individual ADC value model and the individual T2* value model(both P<0.05).Conclusions Multimodal MRI combining DWI,T2* mapping,and SWI can improve differentiation between PCa and BPH.The combined application of DWI and T2* mapping demonstrates high diagnostic value.
Keywords：prostate carcinomabenign prostatic hyperplasiamultimodal magnetic resonance imagingdiffusion-weighted imagingT2* relaxation time quantitative imagingsusceptibility-weighted imaging
Publication Date：2026-02-25
Online Publishing Date：2026-03-19(First online date of this platform, not the publication date of the document)
Pages：5( 118-121,126 )