Research progress on BMSCs and their exosomes for the treatment of female stress urinary incontinence
JIANG Nuo
HONG Li
Abstract：Stress urinary incontinence(SUI)is a common pelvic floor dysfunction in women,severely affecting quali-ty of life.While conventional therapies provide symptomatic relief,they often fail to repair the underlying damage to the urethral sphincter and pelvic support structures.With advances in regenerative medicine,bone marrow-derived mesenchy-mal stem cells(BMSCs)and their secreted exosomes have emerged as a promising therapeutic direction for SUI,owing to their abilities to promote tissue regeneration,improve pelvic support,and modulate the inflammatory microenvironment.Evidence indicates that BMSCs facilitate repair through differentiation and paracrine actions,and their efficacy can be fur-ther enhanced via engineering strategies like genetic modification or biomaterial combination.Exosomes derived from BM-SCs serve as a potent cell-free therapy,regulating inflammation and improving tissue elasticity.Preconditioning BMSCs(e.g.,under hypoxia or with inflammatory factors)can significantly alter exosomal composition and bioactivity,boosting their anti-inflammatory,anti-fibrotic,and regenerative potential.Despite promising progress,clinical translation faces challenges related to cell sourcing,delivery methods,engraftment efficiency,safety,quality control,and ethical issues,warranting further systematic investigation to provide theoretical basis and practical reference for the treatment of female SUI.
Keywords：bone marrow-derived mesenchymal stem cellsstress urinary incontinenceexosomesbioengineering techniques
Publication Date：2026-01-25
Online Publishing Date：2026-03-05(First online date of this platform, not the publication date of the document)
Pages：4( 155-158 )