Research progress on role and intervention strategies of ovarian granulosa cell ferroptosis in development and progression of diminished ovarian reserve
ZHANG Xiaoqi
BI Fuxi
Abstract：Ovarian granulosa cells(GCs)are important"mediators"that influence follicular development and play a crucial role in maintaining oocyte growth,hormone secretion,and the homeostasis of the ovarian microenvironment.Fer-roptosis is a novel form of programmed cell death characterized by iron-dependent lipid peroxidation,and it plays an impor-tant role in GC injury and ovarian aging.Ferroptosis of GCs can lead to poor follicular development,thereby reducing oo-cyte quality and ultimately causing diminished ovarian reserve(DOR).Studies have shown that iron metabolism imbal-ance,abnormal lipid peroxidation,dysfunction of the antioxidant defense system,and dysregulation of non-coding RNA(ncRNA)can all induce GC ferroptosis and accelerate the development and progression of DOR.Therefore,inhibiting fer-roptosis by regulating iron metabolism,lipid metabolism,and the antioxidant system in GCs may serve as an effective inter-vention strategy to delay or reverse DOR.This provides a theoretical basis for further exploring the molecular mechanisms of DOR and offers potential directions for developing targeted interventions and novel therapeutic approaches.
Keywords：ovarian granulosa cellsferroptosisdiminished ovarian reserve
Publication Date：2026-01-25
Online Publishing Date：2026-03-05(First online date of this platform, not the publication date of the document)
Pages：4( 151-154 )