Research progress on mechanism of Honghua(carthamus tinctorius)and its active ingredients against atherosclerosis
TANG Huijie
SU Zhouyu
WU Haolin
HUANG Shan
LIU Huajiang
MENG Qingwen
Abstract：Atherosclerosis(AS)is one of the important factors causing cardiovascular diseases,and its incidence rate has been continuously rising with population aging and changes in lifestyles.Honghua(carthamus tinctorius)is a tradition-al Chinese medicine with the efficacy of promoting blood circulation and removing blood stasis.It contains a variety of ac-tive ingredients that can exert anti-AS effects through multiple targets and pathways.Studies have shown that ingredients such as safflower yellow,hydroxy-safflower yellow A,kaempferol,quercetin,and safflower polysaccharides can interfere with the development and progression of AS through various mechanisms,including regulating lipid metabolism,inhibiting inflammatory responses,resisting oxidative stress,suppressing the proliferation and migration of vascular smooth muscle cells,inhibiting the apoptosis of vascular endothelial cells,anti-aging,and reducing platelet aggregation.In addition,as a multi-component medicinal material,Honghua may exhibit synergistic effects among its different active components,which jointly enhance the overall anti-AS effect.A systematic review of the anti-AS mechanism of Honghua is helpful to provide a reference basis for its further clinical transformation and application.
Keywords：Honghua(carthamus tinctorius)anti-atherosclerosisactive ingredients
Publication Date：2026-01-25
Online Publishing Date：2026-03-05(First online date of this platform, not the publication date of the document)
Pages：4( 142-145 )