Research progress on active ingredients of traditional Chinese medicine regulating endothelial dysfunction against atherosclerosis
YANG Xuemei
SUN Yun
HUANG Feng
TONG Xiaoyun
Abstract：Atherosclerosis(AS)is a chronic inflammatory vascular disease and also the core pathological basis of most cardiovascular diseases.Endothelial cells,as a single layer of cells in the inner lining of blood vessels,play a prima-ry barrier role in maintaining the integrity of the vascular endothelium,regulating vascular tension,anti-inflammation,and anti-thrombosis,etc.Therefore,endothelial dysfunction is a key factor in the initiation of AS.Research indicates that en-dothelial dysfunction,which leads to the onset and progression of AS,is promoted by factors as oxidative stress,inflamma-tory responses,programmed cell death and cellular senescence.The active ingredients of traditional Chinese medicine ex-hibit multi-target therapeutic potential against AS.Phenethyl alcohol glycosides,saponins,flavonoids,and alkaloids from traditional Chinese medicine exert effects against AS through multiple pathways and mechanisms.These include antioxi-dant and anti-inflammatory activities,inhibition of endothelial cell apoptosis and pyroptosis,and improvement of endotheli-al barrier function.This review provides traditional Chinese medicine as a promising therapeutic strategy for AS.
Keywords：atherosclerosisendothelial cellsoxidative stressinflammatory response
Publication Date：2026-01-25
Online Publishing Date：2026-03-05(First online date of this platform, not the publication date of the document)
Pages：5( 137-141 )