Comparison of rational antibiotic use in perioperative period of class Ⅰ incision surgeries before and after in-depth involvement of clinical pharmacists in refined management
LYU Mengmeng
LI Ting
WANG Hui
ZHU Huifang
Abstract：Objective To compare the rational use of perioperative antibiotics in general surgery patients undergoing class Ⅰ incisions before and after the in-depth involvement of clinical pharmacists in refined management.Methods A total of 351 antibiotic use records from patients undergoing class I incision general surgery were included,comprising 99 cases before management(May to October 2022),122 cases in the first year after management(May to October 2023),and 130 cases in the second year after management(May to October 2024).A refined management model based on a pre-prescription review system was applied,in which clinical pharmacists performed pre-prescription review according to class I incision antibiotic use rules,combined with real-time intervention,post-prescription evaluation,periodic assessment,and training.The rationality of perioperative antibiotic use before and after management was compared.Results In the first year after management,the rates of rational use regarding antibiotic indication,drug selection,timing of administra-tion,treatment duration,and dosage improved from 29.29%,66.67%,46.46%,67.68%,and 75.76%before manage-ment to 82.79%,86.07%,81.15%,90.98%,and 89.34%,respectively,with statistically significant differences(all P<0.01).In the second year after management,these rates further increased to 90.77%,91.54%,88.46%,95.38%,and 99.23%,all differences reaching statistical significance(all P<0.01).No significant difference was observed in the rationality of repeated medication use before and after treatment(P>0.05).Compared with pre-management,the use of in-appropriate antibiotics,including quinolones,third-generation cephalosporins,penicillins,and nitroimidazoles,de-creased after management,with quinolones showing the most marked reduction(all P<0.05).Conclusion The in-depth involvement of clinical pharmacists in refined management significantly improved perioperative antibiotic use in general surgery patients with class Ⅰ incisions,reduced inappropriate prescriptions,and ensured safe and rational medi-cation.
Keywords：class Ⅰ incisionantimicrobial agentpre-prescription reviewrefined managementclinical pharmacist
Publication Date：2026-01-25
Online Publishing Date：2026-03-05(First online date of this platform, not the publication date of the document)
Pages：5( 122-126 )