Predictive value of SII,NT-proBNP,and LVEF for major adverse cardiovascular events in patients with heart failure with reduced ejection fraction
WANG Fei
LI Yin
LI Jingfeng
Abstract：Objective To evaluate the predictive value of the systemic immune-inflammation index(SII),N-termi-nal pro-brain natriuretic peptide(NT-proBNP),and left ventricular ejection fraction(LVEF)for major adverse cardiovas-cular events(MACE)in patients with heart failure with reduced ejection fraction(HFrEF).Methods A total of 210 HFrEF patients were included and divided into the MACE group(67 cases)and non-MACE group(143 cases)based on the occurrence of MACE during follow-up.General data from both groups were collected and balanced using propensity score matching(PSM),resulting in 58 matched pairs(58 cases in the MACE group and 58 in the non-MACE group)for subsequent analysis.Clinical data,including fasting blood glucose,hemoglobin,SII,troponin,NT-proBNP,serum creat-inine,blood urea nitrogen,and LVEF,were collected and compared between the two groups after PSM.Multivariate Cox regression analysis was used to identify factors influencing MACE in HFrEF patients,and receiver operating characteristic(ROC)curve analysis was performed to evaluate the predictive performance of these factors.Results After PSM,the MACE group had significantly higher levels of SII,troponin,and NT-proBNP,and a lower level of LVEF than the non-MACE group(all P<0.05).Multivariate Cox regression analysis indicated that SII,NT-proBNP,and LVEF were indepen-dent predictors of MACE in HFrEF patients(all P<0.05).The area under the ROC curve(AUC)for SII in predicting MACE was 0.829,with a sensitivity of 0.881 and specificity of 0.811.The AUC for NT-proBNP was 0.780,with a sensi-tivity of 0.776 and specificity of 0.804.The AUC for LVEF was 0.782,with a sensitivity of 0.821 and specificity of 0.811.The combined prediction model of SII,NT-proBNP,and LVEF achieved an AUC of 0.902,with a sensitivity of 0.970 and specificity of 0.783.Conclusions SII,NT-proBNP,and LVEF are independent predictors of MACE in HFrEF patients.The combination of these three markers demonstrates high predictive efficacy for MACE in this patient population.
Keywords：systemic immune-inflammation indexN-terminal pro-brain natriuretic peptideleft ventricular ejec-tion fractionheart failure with reduced ejection fractionmajor adverse cardiovascular eventspropensity score matching
Publication Date：2026-01-25
Online Publishing Date：2026-03-05(First online date of this platform, not the publication date of the document)
Pages：5( 79-83 )