Diagnostic efficacy of serum Cav-1 and sCD163 levels in children with Mycoplasma pneumoniae pneumonia complicated with bacterial infection
TIAN Qiuying
REN Xiaochen
ZHU Yuanyu
Abstract：Objective To explore the diagnostic efficacy of serum Caveolin-1(Cav-1)and soluble hemoglobin scav-enger receptor(sCD163)levels in children with Mycoplasma pneumoniae pneumonia(MPP)complicated with bacterial in-fection.Methods Totally 105 children with MPP were divided into the bacterial infection group of 30 cases and non-bac-terial infection group of 75 cases based on the sputum culture results of the children.Enzyme linked immunosorbent assay was used to detect serum Cav-1 and sCD163 in the pediatric patients of the two groups.The receiver operating characteris-tic(ROC)curve was used to evaluate the predictive value of serum Cav-1 and sCD163 levels for bacterial infection in MPP children.Results The serum levels of Cav-1 and sCD163 in the bacterial infection group were(6.67±1.26)μg/L and(156.69±18.94)pg/mL,respectively.The serum levels of Cav-1 and sCD163 in the non-bacterial infection group were(8.52±1.39)μg/L and(134.78±14.66)pg/mL,respectively;there were significant differences between these two groups(both P<0.05).The area under the curve for diagnosing MPP with bacterial infection using serum Cav-1 level was 0.808(95%CI:0.722-0.895).When the cut-off value was 8.16 μg/L,the sensitivity and specificity for diagnosing MPP with bacterial infection were 90.00%and 62.70%,respectively;the area under the curve for diagnosing MPP with bacterial infection using serum sCD163 level was 0.785(95%CI:0.684-0.885).When the cut-off value was 144.16 pg/mL,the sensitivity and specificity for diagnosing MPP with bacterial infection were 66.70%and 85.30%,respectively.The area under the curve of serum Cav-1 combined with sCD163 levels for diagnosing MPP with bacterial infection was 0.904(95%CI:0.849-0.958),with a sensitivity of 93.33%and specificity of 80.00%for the diagnosis of MPP with bacterial infection.Conclusions The serum Cav-1 level decreases and the sCD163 level increases in children with MPP complicated with bacterial infection.The combined detection of the two has a higher diagnostic efficacy for children with MPP combined with bacterial infection.
Keywords：Mycoplasma pneumoniae pneumoniabacterial infectioncaveolin-1soluble hemoglobin scavenger receptordiagnostic effectiveness
Publication Date：2026-01-25
Online Publishing Date：2026-03-05(First online date of this platform, not the publication date of the document)
Pages：4( 66-68,73 )