Research progress on antibiotic resistance mechanisms of Helicobacter pylori
YANG Tingting
LI Xue
LIU Jun
GUO Xiaole
LIU Yanxia
HU Shengjuan
Abstract：Helicobacter pylori(H.pylori)infection is a significant causative factor in chronic gastritis,peptic ul-cers,and gastric cancer.With the widespread use of antibiotics in clinical practice,the resistance rates of H.pylori to clarithromycin,metronidazole,and levofloxacin have been progressively increasing.Antibiotic resistance in H.pylori has become a major challenge in clinical eradication therapy.The mechanisms of H.pylori resistance are complex and involve alterations in antibiotic target sites,efflux pump systems,drug-degrading enzyme systems,and biofilm formation,among others.A deeper understanding of the resistance mechanisms of H.pylori may provide new insights for the development of novel approaches to eradication therapy.
Keywords：Helicobacter pyloriantimicrobial agentsresistance mechanism
Publication Date：2025-12-25
Online Publishing Date：2026-01-12(First online date of this platform, not the publication date of the document)
Pages：6( 153-158 )