Research progress on dioscin regulating bone metabolism-related signaling pathways for the prevention and treatment of osteoporosis
HUANG Tingting
WANG Anning
ZHAO Wenzhuo
YU Langqing
SHAO Shoutao
WANG Weiguo
Abstract：Osteoporosis is a bone metabolic disease characterized by decreased bone mass,destruction of bone micro-structure,increased bone fragility,and increased susceptibility to fractures.Its occurrence is closely related to various fac-tors such as aging,changes in hormone levels,nutritional deficiencies,and drug effects.Dioscin(Dio)is a natural active component widely distributed in the roots,stems,leaves and other parts of medicinal plants of the Dioscoreaceae family such as yam and pangolin.It has anti-inflammatory,liver-protecting,antioxidant and anti-tumor effects.Dio regulates bone metabolism-related signaling pathways such as the Hedgehog signaling pathway,P53 apoptosis-stimulating protein 2 antibody/nuclear factor κB signaling pathway,osteoproteinin/nuclear factor κB receptor activator ligand/nuclear factor κB receptor activator signaling pathway,and phosphatidylinositol-3 kinase/protein kinase B/mitogen-activated protein kinase signaling pathway.It affects the expression of key bone metabolism-related factors,promotes the proliferation,differentia-tion and bone formation of osteoblasts,and simultaneously inhibits the generation and bone resorption activity of osteo-clasts,exerting the preventive and therapeutic effects of OP.A thorough understanding of the mechanism of Dio in the pre-vention and treatment of OP can provide new ideas for subsequent research on the prevention and control of OP.
Keywords：dioscinbone metabolismHedgehog signaling pathwayASPP2/NF-κβ signaling pathwayOPG/RANKL/RANK signaling pathwayPI3K/AKT/MAPK signaling pathway
Publication Date：2025-12-25
Online Publishing Date：2026-01-12(First online date of this platform, not the publication date of the document)
Pages：5( 126-129,134 )