Application effect of intravenous injection of remimazolam besylate on painless gastroscopy for pediatric patients
WANG Di
ZHAO Xin
WANG Fengjuan
XIE Kun
Abstract：Objective To evaluate the application effect of intravenous injection of remimazolam besylate on pain-less gastroscopy for pediatric patients.Methods Prospectively,60 pediatric patients aged 6-14 years scheduled for pain-less gastroscopy were prospectively enrolled and assigned into the remimazolam group and propofol group using a random number table,with 30 patients in each group.During preoperative anesthetic induction,both groups initially received fen-tanyl 1 μg/kg intravenously,followed by intravenous administration of remimazolam besylate 0.2 mg/kg in the remimazol-am group and propofol 2 mg/kg in the propofol group,with rescue sedation provided based on Modified Observer's Assess-ment of Alertness/Sedation(MOAA/S)scale scores.During gastroscopy procedures,both groups received multiple supple-mental doses of remimazolam besylate 0.05 mg/kg or propofol 0.5 mg/kg,respectively,based on the children's response.A comparison was made between the two groups regarding sedation success rate,times of remedial sedation,sedation onset time,awakening time,and recovery time,as well as changes in heart rate,pulse oxygen saturation,and blood pressure be-fore and after induction.Anesthesia-related adverse reactions were also documented for both groups.Results All 60 pe-diatric patients successfully completed anesthetic induction,achieving sedation success rate of 100%in both groups.Com-pared with the propofol group,the remimazolam group demonstrated a higher proportion of cases requiring≥2 remedial se-dation interventions and significantly shorter awakening time and recovery time.Compared with the propofol group,the remimazolam group exhibited significantly higher mean arterial pressure at 0 minute,1 minute and 5 minutes post-induc-tion(P<0.05).Compared with the propofol group,the remimazolam group showed significantly lower incidences of hypo-tension and injection pain(P<0.05).Conclusion Intravenous injection of remimazolam besylate demonstrates excel-lent sedative efficacy for painless gastroscopy in pediatric patients,effectively reduces awakening time and recovery time,and is associated with fewer adverse reactions.
Keywords：remimazolam besylatepainless gastroscopysedative efficacy
Publication Date：2025-12-25
Online Publishing Date：2026-01-12(First online date of this platform, not the publication date of the document)
Pages：4( 104-107 )