Clinical effect of spraying fibrin glue on the wound surface after endoscopic submucosal dissection for large gastric lesions
YANG Zhenzhen
PAN Xiaolin
WEI Wenjun
SHU Xu
ZHOU Xiaodong
CHEN Youxiang
Abstract：Objective To explore the clinical efficacy of porcine fibrin glue in the wound surface after endoscopic sub-mucosal dissection(ESD)for larger gastric lesions(maximum diameter of the lesion≥2 cm and<5 cm).Methods Ninety cases of ESD due to benign submucosal lesions of the stomach and early gastric cancer were selected and divided into the study group and control group,with 45 cases in each group.In the study group,we sprayed fibrin glue on the surgical wound before the endoscopic withdrawal operation was completed,while in the control group,we did not perform this oper-ation.The incidence of postoperative complications,length of hospital stay,hospitalization expenses and wound healing rate one month after surgery were compared between the two groups.Results No perforation occurred in either group af-ter the operation.There were 3 cases of postoperative fever in both the study group and the control group,and they recov-ered well after anti-infection and symptomatic treatment.In the study group,there was 1 case(2.22%)of postoperative bleeding,and in the control group,there were 5 cases(11.11%)of postoperative bleeding.All the bleeding was success-fully stopped by gastroscopy surgery.The incidence of postoperative bleeding in the study group was lower than that in the control group(P<0.05).Gastroscopy was reexamined one month after the operation.The wound healing rates of the study group and the control group were 93.33%(42/45)and 77.78%(35/45),respectively.The wound healing rate of the study group was higher than that of the control group(P<0.05).There were no statistically significant differences in the length of hospitalization or hospitalization cost between the two groups(both P>0.05).Conclusion For larger gastric le-sions,spraying fibrin glue on the wound surface after ESD can effectively reduce the incidence of postoperative bleeding,improve the wound healing rate,and will not significantly increase the length of hospital stay and cost.
Keywords：fibrin gluelarge lesions in the stomachendoscopic submucosal dissectionwound treatment
Publication Date：2025-12-25
Online Publishing Date：2026-01-12(First online date of this platform, not the publication date of the document)
Pages：5( 95-99 )