Correlations between serum interleukin expression profile and pan-immune inflammatory indicators and prognosis in patients with active pulmonary tuberculosis
Mairijiangguli Abulitifu
Maliyamu Abulitifu
WANG Quan
YANG Xiumei
Abstract：Objective To explore the relationships between the serum interleukin(IL)expression profile,pan-im-mune inflammation indices,and prognosis in patients with active pulmonary tuberculosis(PTB).Methods Totally 204 patients with active PTB were selected.All patients received a 2-month intensive treatment regimen consisting of isonia-zid,rifampicin,pyrazinamide,and ethambutol,followed by a 10-month consolidation treatment with two core anti-tuber-culosis drugs,isoniazid and rifampicin.The prognosis of the patients was evaluated.Relevant prognostic data were collect-ed.Flow cytometry was used to detect the pre-treatment serum IL expression profile,including IL-1β,IL-2,IL-4,IL-6,IL-10,IL-12,and IL-17.An automated hematology analyzer was employed to measure the pre-treatment pan-immune in-flammatory indicators lymphocyte count,neutrophil count,monocyte count,platelet count,C-reactive protein,and albu-min levels.The pan-immune inflammation index(PIV),neutrophil-to-lymphocyte ratio(NLR),monocyte-to-lymphocyte ratio(MLR),and C-reactive protein-to-albumin ratio(CAR)were calculated.Univariate and multivariate Logistic regres-sion analyses were conducted to assess the impact of the serum IL expression profile and pan-immune inflammation indices on the prognosis of patients with active PTB.Results Among the 204 patients with active PTB,136 had a favorable prog-nosis and 68 had an unfavorable prognosis.Compared with patients with a favorable prognosis,those with an unfavorable prognosis had higher proportions of comorbid diabetes,smoking history,fever,and cavitary lesions(all P<0.05),as well as higher serum levels of IL-1β,IL-4,IL-6,IL-12,and PIV(all P<0.05).Elevated serum levels of IL-1β(OR=1.080,95%CI:1.027-1.137),IL-4(OR=1.057,95%CI:1.013-1.103),IL-6(OR=1.089,95%CI:1.039-1.142),IL-12(OR=1.020,95%CI:1.007-1.033),and PIV(OR=1.001,95%CI:1.001-1.002)were risk factors for the prognosis of patients with active PTB(all P<0.05).Conclusion Patients with active PTB who have elevated serum levels of IL-1β,IL-4,IL-6,IL-12,and PIV are more likely to have an unfavorable prognosis.
Keywords：active pulmonary tuberculosispan-immune inflammatory indicatorsinterleukin expression profileprognosisinfluencing factors
Publication Date：2025-11-25
Online Publishing Date：2025-12-09(First online date of this platform, not the publication date of the document)
Pages：5( 82-86 )